NR0B1 and leukemia: However, CHIC1 and CHIC2 were both originally identified as Brain x-linked protein (Brx) and BrX-like translocated in leukaemia (BTL), respectively, and their roles in the regulation of nuclear hormone receptors (Kino et al. 2006) and exocytosis (Cools et al. 2001) have been described.