However, CHIC1 and CHIC2 were both originally identified as Brain x-linked protein (Brx) and BrX-like translocated in leukaemia (BTL), respectively, and their roles in the regulation of nuclear hormone receptors (Kino et al. 2006) and exocytosis (Cools et al. 2001) have been described. The gene discussed is CHIC2; the disease is leukemia.