Yin et al. [54] reported that homozygous deletion of exon 5 of FHIT was positively associated with lymph node metastasis of differentiated thyroid cancer and the homozygous deletion of exon 8 was positively associated with the tumor pathological grade, TNM staging, and lymph node metastasis of differentiated thyroid cancer. The gene discussed is FHIT; the disease is metastatic malignant neoplasm in the lymph nodes.