Here, our meta-analysis showed FHIT expression was inversely linked to depth of invasion, lymph node metastasis, distant metastasis and TNM staging of gastric cancer, indicating that its hypoexpression promoted invasion and metastasis of gastric cancer, in agreement with the reports about oral squamous cell carcinoma [55], cholangiocarcinoma [56], colorectal cancer [57], and cervical cancer [58]. This evidence concerns the gene FHIT and colorectal cancer.