As shown in Figure 1, the expression of MARCH1, MARCH2, MARCH3, MARCH8 and MARCH10 decreased significantly in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) compared to normal lung tissue, and MARCH9 mRNA level decreased significantly in LUSC. The gene discussed is MARCHF8; the disease is squamous cell lung carcinoma.