Human epididymis protein 4 (HE4) was shown to be overexpressed in serous and endometrioid epithelial ovarian carcinomas and uterine cancers and to a lesser extent in pulmonary, breast, gastrointestinal, and urological carcinomas [21] and is often detectable in the bloodstream of cancer patients including patients with endometrial carcinoma [22–25]. The gene discussed is WFDC2; the disease is cancer.