MUC16 and endometrial cancer: The aim of this multicentre international study is to evaluate preoperative circulating biomarkers CA125, HE4, and HE4ren (HE4 level adjusted to glomerular filtration rate), together with histological grade and age in predictive models of the depth of myometrial invasion in endometrial cancer patients to i) identify cases that would benefit from lymphadenectomy and ii) exclude from extensive surgery those that would not.