AKT1 and neoplasm: Serine/threonine kinases of the mitogen-activated protein kinases (MAPKs) such as p38-MAPK, extracellular response kinases (ERK) and mediators of the phosphoinositide 3-kinase (PI3K) signaling pathway such as protein kinase B (PKB/AKT) play paramount roles in tumor growth and angiogenesis [14, 15].