The presence of rshCD5 in the tumor environment was able to mimic the changes in TdLNs observed in shCD5EμTg mice (increased total CD4+ and CD8+ T-cell numbers and decreased proportion of Treg cells), but also to induce increased total NK and NKT cells –two cell types involved in non-specific anti-tumor responses. The gene discussed is CD4; the disease is neoplasm.