UBR5 and colorectal carcinoma: In the gene-dosage analysis, significant positive correlations were found between the UBR5 gene copies and the UBR5 mRNA levels measured by RNA-seq (n = 376, R2 = 0.436, P < 0.001) or Agilent array (n = 217, R2 = 0.380, P < 0.001), which indicated that copy number gains might be an important contributor to the elevated UBR5 expression in CRC (Figure 1C).