UBR5 and colorectal carcinoma: According to the UBR5 copy numbers obtained from the GISTIC2 threshold, gains and losses of chromosomal regions harboring the UBR5 gene were observed in 58% and 2.1% of CRC cases in The Cancer Genome Atlas (TCGA) cohort, respectively, indicating that the DNA copy of UBR5 was significantly amplified (P < 0.001) in CRC.