In these investigations, dormancy-associated gene expression was affected by TMZ-treatment only to a moderate degree in some GBM cells (A172, 27/07, 86/13 and 141/15), while other ones (LN229, U251MG, 116/14, 124/15) responded to higher extents, and expression of especially IGFBP5 and H2BK were induced considerably. The gene discussed is IGFBP5; the disease is glioblastoma.