As shown in Figure 4, knockdown of NCOA5 by shNCOA5 3# remarkably retarded SW620 CRC cell growth in vivo (tumor volume, P<0.05 at week 2, and P<0.01 at week 3 and 4; tumor weight, P<0.01), whereas overexpression of NCOA5 promoted SW480 CRC cell growth (tumor volume, P<0.05 at week 2, and P<0.01 at week 3 and 4; tumor weight, P<0.01). The gene discussed is NCOA5; the disease is colorectal carcinoma.