YAP1 and colorectal cancer: Consistent with these observations, we found that the expression of YAP1 in small colorectal cancer cells was higher than the corresponding large cells, and furthermore, knockdown of YAP1 decreased the stemness (Figure 5D–5I) and metastatic capacity (Figure 6A–6D) of small CRC cells, while those were little affected in large CRC cells upon knocking down of YAP1.