This study demonstrates, for the first time, that a single noncoding RNA associates with clinical outcome in T-LBL, in the context of the well-established molecular marker NOTCH1. Of note, when we combined miR-223 expression levels and NOTCH1 mutational status, we observed that miR-223 outweighs the prognostic value of NOTCH1. Existing evidence in T-ALL showed miR-223 as promoter in the development of leukemia [12] and it was demonstrated that over-expression of miR-223 is an additional way of NOTCH1 signaling activation [18]. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.