IGFBP1 and hepatocellular carcinoma: IGFBP-1 is an early-response factor rapidly induced by glucocorticoids, pro-inflammatory cytokines and ROS [154, 155] as well as other stress-related events [156, 157] with hepatic IGFBP-1 mRNA expression being also increased in alcoholic liver disease, cirrhosis [156], hepatocellular carcinomas [158] and steatosis [159].