THBS1 and Hepatic fibrosis: Several studies reported increased expression of THBS1 in hepatic fibrosis and hepatocellular carcinoma [130, 135, 136], and a recent review summarizes the function of THBS1 and its activity via CD47 in inhibiting NO, cGMP, cAMP and VEGF signalling to promote thrombosis and to decrease tissue survival [137].