Increased KLF6 expression augments enhanced collagen 1 and TGFß1 expression to result in liver fibrosis [213], and overexpression of KLF2 induces expression of the fatty acid translocator CD36 [214] whereas KLF15 plays an essential role in ER stress-mediated insulin resistance in the liver [215]. This evidence concerns the gene INS and Hepatic fibrosis.