In turn, the greater BST2 gene expression levels found here among non-MTX tumors, could potentially be more related to the immunomodulatory role of stromal cells expressing BST2 in non-MTX sCRC, rather than the tumor cell-specific expression levels per se; this would contribute to explain, at least in part, the apparent discrepant findings in the literature [62]. The gene discussed is BST2; the disease is neoplasm.