Up-regulation of the SPP1, miR-122, SRPX2, ADH1B, miR-21, SALL4 and PRAP1 genes, as well as down-regulation of miR-378e have been previously associated with an increased tumor cell migration capacity among sCRC [44–46], greater tumor progression potential [45, 47, 48], a metastatic phenotype [10, 45, 48, 49] and inhibition of apoptosis [50, 51]. The gene discussed is SPP1; the disease is neoplasm.