CRK and toxoplasmosis: In parallel, genes that participate in pro-inflammatory and/or protective immune functions were also downregulated in MTX sCRC such as pro-inflammatory effector genes involved in FcγR-mediated phagocytosis and/or the toxoplasmosis pathways (e.g. the PIP5K1B, CRK, PLA2G2A, PLA2G4A, PLPP1 and PLPP3 genes) and chemokines responsible for leucocyte migration (e.g. CXCL12).