PIGR and digestive system neoplasm: Metastatic sCRC tumors also showed high-level down-regulation of tumor suppressor miRNAs, including members of the miR-378 family (miR-378, miR-378c, d and e) and miR-422a, together with loss of expression of the ADGRG7 gene involved in cell adhesion, and genes previously described to be silenced during progression and/or invasion of gastrointestinal tumors (e.g. the PIGR and ADH1B genes).