This included down-regulation of genes associated with FcγR-mediated phagocytosis and leucocyte migration [25, 30], together with overexpression of VEGFA [31], suggesting that the migration and establishment of colorectal tumor cells at distant (i.e: metastatic) sites might only occur in a microenvironment depleted of pro-inflammatory signals provided by e.g. locally recruited immune cells in response to injury [32]. Here, VEGFA is linked to colorectal neoplasm.