Large-scale genome-wide association studies (GWAS) have identified loci conferring risk to ischemic stroke, including variants in 11q12.1 (APLNR), 12p13 (NINJ2), 12q24 (ALDH2), 7p21 (HDAC9), 9p21 (ANRIL), 4q25 (PITX2), 16q22 (ZFHX3), 9q34 (ABO), and 1p13.2 (TSPAN2) [8–14]. This evidence concerns the gene APLNR and ischemic stroke.