HLA-G and colorectal carcinoma: Applying HLA-G expression above the cut-off level at 5% (HLA-GLow) as positive which were commonly used in previous studies, HLA-GLow was not significantly related to the CRC patient survival; however, when HLA-G expression above the level of 55% (HLA-GHigh), HLA-GHigh reaches a statistic significance point to a worse survival, which echoes a study by Kirana et al. [22] that high, but not negative and moderate local HLA-G expression was closely linked to the CRC patient survival.