HGF and breast cancer: Moreover, overexpression of the wild type EcSOD with an adenovirus vector (AdEcSOD) suppressed the HGF-stimulated Matrigel invasion of MDA-MB468 cells (Figure 1G-top panel), whereas the mutant EcSOD has no influence on the invasiveness of breast cancer cells, when conditioned media harvested from RMF-HGF fibroblasts were used as a chemoattractant (Figure 1G-bottom panel).