In a prolonged co-culture study where breast cancer cells were seeded for multiple passages with mammary fibroblasts, followed by re-isolation of individual cell types, overexpression of EcSOD significantly suppressed the invasiveness of breast cancer cells that were pre-exposed to HGF-secreting fibroblasts, when compared to the parental MDA-MB231 cells. The gene discussed is SOD3; the disease is breast carcinoma.