Finally, we perform experiments with anti-PD-L1 antibodies using the MC38 cell line and another CRC cell line which is a model for non-hypermutated/MSI- CRC (CT26 (Colon Tumor #26)) and show how targeting the PD-1/PD-L1 pathway modulates immunoediting. This evidence concerns the gene CD274 and colorectal carcinoma.