Moreover, application of the AT1 receptor blocker telmisartan (10 mg/kg/d in drinking water for 28 days, Supplementary Fig. 1b, Supplementary Table 3), abolished HHcy-enhanced AAA formation in WT mice (Supplementary Fig. 3a–c), reinforcing that the AT1 receptor mediated HHcy-aggravated vascular aneurysmal injury. This evidence concerns the gene AGTR1 and triple-A syndrome.