If the hepatic levels of NAD+ and of keratin 8 and GKRP deacetylation reflect hepatic Sirt2 activity, it is plausible that a decrease in Sirt2 activity in the obese diabetic livers results in compromised regulation of HGU and glucokinase translocation by postprandial hyperglycemia. This evidence concerns the gene GCKR and Hyperglycemia.