This SOX10-dependent induction of FOXD3 by inhibition of ERK1/2 signaling is durable for at least 120 h (Supplementary Figs. 1 and 16) and is also present in melanoma cells treated with a combination of RAF and MEK inhibitors (Supplementary Figs. 2, 17, 18). Here, MAPK3 is linked to melanoma.