Moreover, the identification of the let-7d-3p-dependent regulation of Dnmt1 in type 2 diabetic HSCs, which regulates the genes responsible for HSC differentiation towards monocytes as well as their M1/M2 polarization, creates an excellent opportunity for the development of biological therapeutics to restore normal wound healing in people with T2DM. The gene discussed is DNMT1; the disease is type 2 diabetes mellitus.