MEM identified changes in populations between ciromicin A and ciromicin B, including greater enrichment for CD13, a marker of myeloid differentiation, and CD43, or sialophorin, which is commonly expressed on more mature myeloid cells such as granulocytes and monocytes, after treatment with ciromicin A within a major leukemia population (subset 9, Fig. 5b). This evidence concerns the gene SPN and leukemia.