Interestingly, Wnt signaling is linked to branching morphogenesis42, 43 and a subset of tumor-associated macrophages that drive invasive cancer dissemination through TMEM formation also secrete Wnt ligands31, while CCL2 production by colorectal cancer cells can also foster vascularization and intravasation as shown in more advanced tumors44. Here, CCL2 is linked to neoplasm.