TNFRSF9 and neoplasm: We previously showed that combination treatment with IL-2 and agonistic anti-CD137 elicited potent anti-tumor immunity, but was also accompanied by severe systemic toxicity unless these agonists were confined to tumors by intratumoural injection of the cytokine and antibody covalently anchored to lipid nanoparticles, blocking their dissemination beyond the tumor and tumor-draining lymph nodes (TDLNs)11.