Both soluble and liposomal αCD137/IL-2-Fc induced intracellular pSTAT5 activation in CD8 T-cells and NK cells in both primary (Fig. 7j) and lung metastatic (Fig. 7k) melanoma models, with the soluble agents activating pSTAT5 in NK cells slightly more effectively than liposomes. This evidence concerns the gene IL2 and melanoma.