IL2 and neoplasm: We previously showed that conjugation of IL-2 and anti-CD137 to liposomes for intratumoural injection controlled tumor progression without toxicity11, demonstrating that IL-2/anti-CD137 signaling confined to tumors and TDLNs is sufficient for anti-tumor efficacy, suggesting that the toxicity arising from systemic exposure to these agents is separable from anti-tumor activity.