The CD137 ligand (CD137L) is a member of the tumor-necrosis factor (TNF) superfamily that binds CD137 to provide co-stimulatory signals for T-cell activation, and has been shown to have anti-tumor effects in a number of models when it binds to CD137 receptors to induce costimulation on T-cells9. The gene discussed is TNF; the disease is neoplasm.