In animals receiving an isotype control in lieu of depleting antibodies, the combination therapy triggered sustained inflammatory cytokine/chemokine levels in serum that either increased or were sustained from day 10 to day 13 post tumor inoculation, while depletion of either CD8+ T-cells or NK cells during treatment in wild-type mice greatly reduced the cytokine storm elicited by the combination therapy at these time points (Supplementary Fig. 3b). Here, CD8A is linked to neoplasm.