11β-HSD1, known to catalyze the oxoreduction of cortisone as well as that of 7-ketocholesterol and 7-ketolithocholic acid (38), is expressed in only 1 of the 3 cell lines investigated in the present study (SUM159) and thus cannot explain the effects of H6PD knockdown on the proliferation and migratory potential of the 3 different breast cancer cell lines. Here, H6PD is linked to breast carcinoma.