Higher levels of AMPK (unpaired t test: t(39) = 2.17, p = 0.035; Fig. 9C) and pan-NR4A1 (unpaired t test: t(39) = 2.31, p = 0.025; Fig. 9D) were found in AD patients compared with control subjects. Here, NR4A1 is linked to Alzheimer disease.