This prompted us to validate results from animal studies to human studies of major depressive disorders (MDDs) and Alzheimer's disease (AD), as neuropathology in both diseases is aggravated by stress involving synaptic loss in PFC, disrupted CORT levels, and cognitive impairment (Lupien et al., 2009; Sotiropoulos et al., 2011; Heim and Binder, 2012). This evidence concerns the gene CORT and Alzheimer disease.