NR4A1 and psychiatric disorder: NR4A1 is a transcription factor that we found deregulated in PFC of animal models of stress and excessive CORT levels, and in humans in whom mental health diseases for which disrupted CORT levels and stress are established aggravating factors were diagnosed (de Quervain et al., 2004; Holsboer and Ising, 2010; Machado et al., 2014; Duman et al., 2016).