Additional deletions in cases with ≥30% CR/IDC included the “Down syndrome critical region” located between ERG and TMPRSS2 on 21q22 [48], 16q22 (CTCF) [49], 13q14 (RB1) [50, 51], 17p13 (TP53) [52], and parts of 6q [53, 54] (Additional file 4: Table S3). This evidence concerns the gene TMPRSS2 and Down syndrome.