CFR in the left anterior descending coronary artery was measured by transthoracic Doppler echocardiography, at rest and during adenosine infusion, in a prospective study of 37 consecutive psoriasis patients (31 male; age, 37.7 ± 8.5 years) without cardiovascular disease, before and after an average of 6.3 months (range 5.5–7.1 months) of anti-TNF treatment [127]. This evidence concerns the gene TNF and cardiovascular disorder.