Specifically, TNF inhibitors were linked to reduced incidence of myocardial infarction compared with topical/photo or methotrexate treatment (RR, 0.73; 95% CI, 0.59 to 0.90; and RR, 0.65; 95% CI, 0.48 to 0.89; respectively). This evidence concerns the gene TNF and myocardial infarction.