Therefore, this present study focused on the sequence and structural analysis, as well as the immunoinformatic investigation of the hydrophobicity, antigenicity, surface accessibility, and epitopes location of major histocompatibility complex class I chain-related protein A (MIC-A), which is one of the NKG2D ligands that activate the NKG2D receptors on natural killer cells as well as T-cells that serve as innate immunity against tumour growth. The gene discussed is KLRK1; the disease is neoplasm.