MTOR and cancer: Recently, we reported that fascaplysin exerts anti-cancer effects through the down-regulation of survivin and hypoxia inducible factor-1ɑ (HIF-1ɑ) by suppressing mechanistic target of rapamycin (mTOR)-eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1)-mediated 5′-cap-dependent translation [5].