In a recent series of elegant studies, Hankir and collaborators show that the rerouting of the intestine restored and enhanced intestinal synthesis of oleoylethanolamide, a lipid satiety factor and PPAR-α agonist that is reduced in obesity, which, via vagal activation, dramatically increased dorsal striatal dopamine signaling in response to high-fat food [45]. The gene discussed is PPARA; the disease is obesity due to melanocortin 4 receptor deficiency.