PPARG and hepatocellular carcinoma: It is well known that aminoimidazole-4-carboxamide riboside (AICAR) and metformin, known as AMPK activators, decrease the transcriptional activity of the PPARγ/retinoid X receptor (RXR) in the rat hepatoma cell line H4IIEC3, whereas compound C (6-4[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine), known as an AMPK inhibitor, reversed the effects of AICAR and metformin [46].