This classification divided GC in four subgroups represented by: Microsatellite Stable/epithelial-to-mesenchymal transition (MSS/EMT), Microsatellite Stable TP53-positive (MSS/TP53+, somehow overlapping with EBV type of TCGA classification), Microsatellite Stable TP53-negative (MSS/TP53−, similar to CIN by TCGA), and Microsatellite Instable (MSI). The gene discussed is TP53; the disease is gastric cancer.