In the classic CCl4-induced liver fibrosis mouse model, BMP7 antifibrotic effects have been proposed to rely on its crosstalk with EGFR and TGF-β1, by suppressing their expression and inhibiting activation of EGFR [112] and abolishing the accumulation of hepatocyte-derived fibroblasts via EMT [112]. Here, TGFB1 is linked to Hepatic fibrosis.