Hsp functions in the immunology of HIDs could be attributed to their diverse properties: (1) their ability to assemble immune system apparatus to infectious sites; (2) they are capable of interacting with antigen-presenting cells and initiating CD8+ immune responses and are, therefore, seen as potential cancer vaccines; (3) their ability to refold denatured proteins, including most immune cells, thus promoting their survival under stressful conditions [28,29]. Here, HSP90B2P is linked to cancer.