Hsp70 and Hsp60 in particular have been reported to form part of the auto-antigen complex capable of eliciting immunoregulatory cascades, thus suppressing the immune response which is commonly observed in various HIDs, such as Type 1 diabetes, atherosclerosis, rheumatoid arthritis, asthma, and allergies [27]. Here, HSPD1 is linked to rheumatoid arthritis.