TP53 and cancer: Overexpression of Hsp27 in prostrate, ovarian and bladder cancers have been shown to correlate with down-regulation of p53 induced-stimulation of the p21 gene and up-regulation of matrix metalloproteins (MMPs), proteins that are known to pave the way for cancer cell migration, invasion, proliferation, and metastasis, thereby inhibiting p53 mediated senescence, apoptosis and cell cycle arrest [115].