We, therefore, proposed that induction of HSPs prior to inflammation and carefully regulation of ROS, inflammation and apoptosis through the induction of HSPs as well as the inhibition of HSPs in cancer and certain HIDs (asthma and ARDS) and enhancement of HSP activities in RA may, and will, serve as future study references as proposed in the model (Figure 1), which highlights the possible roles of HSPs in HIDs and cancer. This evidence concerns the gene HSP90B2P and acute respiratory distress syndrome.