Diminishing the action of the insulin/IGF1-signaling pathway also postpones age-dependent changes in some disease models, including models of age-dependent paralysis due to the expression in body wall muscles of an aggregation-prone polyglutamine-containing protein or the human protein Aβ1-42 linked to Alzheimer’s disease [58,59]. This evidence concerns the gene IGF1 and early-onset autosomal dominant Alzheimer disease.