CAT and myalgic encephalomeyelitis/chronic fatigue syndrome: In a murine model of chronic fatigue syndrome (myalgic encephalomyelitis), desipramine has been found to attenuate oxidative stress, as well as decreasing the immobility time, increasing locomotor activity and diminishing anxiety; in particular, there was a dose-dependent increase in reduced glutathione, a dose-dependent increase in catalase, and a dose-dependent reduction in nitrite levels [308].