Finally, there are several studies reporting increased activity of the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or Nrf2) and of antioxidant response elements (ARE) in the brain and periphery but that this increased activity is unable to prevent the oxidative damage to molecules in the environment of chronically increased ROS and RNS seen in MS patients [70, 75, 76]. Here, NFE2L2 is linked to myeloid sarcoma.