Together, therefore, our findings of weak functional connectivity in deep nuclei and brainstem nodes (Fig. 2B) might mask meaningful functional connectivity within and between these regions, accounting for the restricted and stereotyped pattern of tau accumulation in early PSP (Ellison et al., 2012) and cortical escape in advanced PSP (Schofield et al., 2012). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.