For Alzheimer’s disease, a negative relationship was confirmed (Z = −13.0, P < 0.0001); for PSP there was a positive relationship (Z = 14.8, P < 0.0001); while for controls no relationship was demonstrated using either whole brain (Z = −1.1, P = 0.27) or deep brain (Z = 1.1, P = 0.27) tau burden. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.