In addition, (iv) with respect to insulin sensitivity: for Adamts5-/--J mice a 50% lower HOMA-IR was found in the DIO model as compared to WT mice, as also seen in the Adamts5-/--P mice (which was confirmed by insulin tolerance tests) [14], and (v) with respect to NASH: Adamts5-/--J mice had lower liver weight and hepatic triglyceride content and developed less steatosis or fibrosis, as shown by histological stainings and expression of marker genes (as observed for the Adamts5-/--P mice). Here, ADAMTS5 is linked to steatosis.