Liver expression of the steatosis markers Cd36 (Cluster of differentiation 36) and Fasn (Fatty acid synthase) and the fibrosis markers Timp1 (Tissue inhibitor of metalloproteinases 1), Col1a1 (Collagen type 1) and Tgfβ1 (Transforming growth factor β1) was significantly lower for Adamts5-/--J as compared to WT mice (Fig 6B). The gene discussed is TIMP1; the disease is steatosis.