While CCT6P1 has not been directly implicated in CHD, the CCT complex has been shown to interact with LOX-1, a receptor involved in atherogenesis.[49] The first tag SNP, rs6418712, maps to an X chromosome locus (giving us absolute gender), containing a poorly characterized transcript whose highest expression is in blood; NHS, which is an actin remodeling regulator, and several microRNAs. The gene discussed is ENSG00000291124; the disease is coronary artery disorder.