This gene is part of the adenosine deaminase family.[31] Previous studies have examined the relationship between genes in the adenosine deaminase gene family and CHD [32–34], given the important cardioprotective role of adenosine.[35] The inclusion of epigenetic signatures is particularly attractive given the challenges and limitations in using multivariate risk models consisting of conventional risk factors to predict the risk for CHD. This evidence concerns the gene ADA and coronary artery disorder.