However, despite no change in viral replication between the control and LD reduced cell lines, we saw a significant increase in the expression of both IFN-β and IFN-λ at 8 hrs post infection, with a marked increase in expression observed in the control cells versus the LD reduced cells (30 fold and 10 fold respectively, p<0.001, Fig 5B and 5C). This evidence concerns the gene IFNB1 and infection.