We also previously reported that while DC10 are effective in dampening the asthma phenotype in mice, including significantly reducing the plasma levels of OVA-specific IgG1 [16], neither immature or TNF-matured OVA-presenting DC or irrelevant allergen-presenting DC10 are effective in reversing the asthma phenotype in mouse models (16). This evidence concerns the gene FBXO8 and asthma.