IGHE and asthma: IgE sensitizes mast cells and basophils for degranulation following allergen cross-linking of IgE-occupied Fc-epsilon-RI [6], while IgG1 antibodies are thought to form immune complexes with allergen within the lungs, thereby recruiting downstream asthma-associated innate cells such as mast cells, basophils, and eosinophils that carry activating Fc-gamma receptors (i.e., in mice, Fc-gamma-R1, -RIII and–RIV) [4,5].