TRPV4 and melanoma: Here, our electrophysiological study provides new knowledge by showing functional expression of TRPV4 channels in the cell membrane of A375 melanoma cells as undoubtedly concluded from the pharmacological and biophysical fingerprints of the current (Figs 1 and 2), such as, activation by the selective activator, GSK1016790A, inhibition of currents by selective inhibitor, HC067047, mild N-shape IV relationship, and calcium permeability.