A similar functional expression and gene expression of TRPV4 was found in the amelanotic melanoma cell line, A375, and the melanotic melanoma lines MKTBR and SK-MEL-28, which is important to know since melanogenesis modulates expression of several genes such as the hypoxia-inducible factor-1 and related pathways and may thus decide on the availability of a specific target or targeted pathway and/or cancer progression [30]. The gene discussed is TRPV4; the disease is melanoma.