Concerning the other two melanotic melanoma lines, MKTBR and SK-MEL-28, we measured similar TRPV4 currents and found similar expression levels for TRPV4 channels while KCa3.1 expression appeared to lower to some degree in MKTBR and SK-MEL-2 if compared to A375 cells (Fig 2 and S1 Fig). Here, KCNN4 is linked to melanoma.