Visual inspections of respective funnel plots revealed no obvious asymmetry for associations of LEPR Q223R and T2D and LEPR K109R and T2D in total sample (Figs 5 and 6), Chinese populations (S7 and S8 Figs), and non-Chinese populations (S9 and S10 Figs), respectively. Here, LEPR is linked to type 2 diabetes mellitus.