(2) The study examined two most widely studied missense SNPs of LEPR in T2D, i.e., Q223R (rs1137101) and K109R (rs1137100) which were in a moderate level of linkage disequilibrium (LD) (e.g., r2 = 0.3647 in Caucasians [71]), and haplotype-based association analysis could provide more statistical power than single SNP analysis [72–74]. The gene discussed is LEPR; the disease is type 2 diabetes mellitus.