3xtg-AD with 8 weeks of exercise training increased POMC-expressing neuronal population compared to 3xtg-AD (3xtg AD: 22.2 ± 1.6 counts per section versus 3xtg AD+Ex: 28.3 ± 1.5 counts per section) (Fig 5A and 5B). The gene discussed is POMC; the disease is Alzheimer disease.