Enforced expression of miR-34a decreases the invasive capacity of human OSA cell lines in vitro and modulates the progression of OSA lung metastasis in vivo, in part, through direct targeting of oncogenes such as c-Met, sirtuin 1 (SIRT1), and CD44 [42, 43, 54]. Here, SIRT1 is linked to obstructive sleep apnea syndrome.