CCT8 and cancer: While increased expression of TRiC/CCT subunits has been observed in cancer cell lines [74], and increases in CCT8 expression are linked to individual cancers [75, 76], we describe consistent TRiC/CCT upregulation within global cancer chaperome signatures throughout the majority of TCGA solid cancers, or Group 1 cancers, whereas Group 2 cancers lack chaperome and, to large extent, TRiC/CCT upregulation.