MARVELD2 and cancer: Our data suggest that cancers consistently display signatures of elevated proteostasis functional processes such as the chaperome and proteasome-mediated clearance, and are in agreement with the hypothesis that upregulated clearance mechanisms such as the proteasome and increased chaperome topologies, particularly increases in ATP-driven chaperones such as the HSP60 chaperonin complex TRiC/CCT, confer increased proteostasis capacity and survival benefits to cancer cells just like they are essential to stem cell biology.