Lastly, 14 different non-GJB2 HL disease causing variants in 10 genes (CHD7, HDAC8, MITF, NEFL, OTOF, SF3B4, SLC26A4, TECTA, TMPRSS3, and USH2A) were found among 13 patients confirming the extreme genetic heterogeneity of hereditary HL. This evidence concerns the gene SF3B4 and Hodgkins lymphoma.