The constituent expression of all the molecular players crucial for the 5-LOX pathway to generate leukotrienes and the receptors (two LTB4 [BLT1 and BLT2] receptors and two cysteinyl LT [CysLT-R1 and CysLT-R2]) receptors in the adipocyte and the stromal vascular fraction highlight the importance of this pathway in obesity. Here, ALOX5 is linked to obesity due to melanocortin 4 receptor deficiency.