BARD1 and cancer: Here we have analyzed all somatic mutations of BARD1 deposited in COSMIC database by using the Cancer-specific High-throughput Annotation of Somatic Mutations (CHASM) [60] tool to distinguish passenger variation events from driver ones across a cohort of tumors and the Variant Effect Scoring Tool (VEST) [61] to identify variants that affect the molecular function of the protein and prioritize them on the basis of the likelihood of their involvement in human disease (Table 2).